Injectable GLP-1 · Compounded
Compounded Tirzepatide Injections
A once-weekly dual GIP and GLP-1 injection (tirzepatide) used for provider-supervised weight management.
- Once-weekly injection
- Tirzepatide, a dual GIP and GLP-1
- Provider-reviewed before prescribed
- Same price at any dose
Every plan includes
- Licensed provider review of your intake
- Compounded tirzepatide shipped from a licensed pharmacy when prescribed
- Unlimited messaging with your care team and provider
- Free shipping on every order
- Dose adjustments as your provider directs
What it is and how it works
Tirzepatide is a dual GIP and GLP-1 receptor agonist. It works on two gut hormone pathways that help regulate appetite and how full you feel, which is what sets it apart from single-pathway GLP-1 medications.
Taken as a once-weekly injection, tirzepatide is often chosen by women who want a stronger effect on appetite, or who have plateaued on another GLP-1.
Compounded tirzepatide is prepared by a licensed compounding pharmacy. A Josie provider reviews your health history and intake before any prescription is issued, and supports you with dose adjustments over time.
Who it’s for
May be a fit if you
- Are exploring provider-guided weight management
- Want a dual-pathway option for appetite control
- Have plateaued on a single-pathway GLP-1
- Want licensed provider oversight and ongoing support
Not appropriate if you
- Have a personal or family history of medullary thyroid carcinoma or MEN 2
- Are pregnant, trying to conceive, or breastfeeding
- Have a history of pancreatitis or certain GI conditions (discuss with your provider)
- Are advised against GLP-1 care by your provider
Eligibility is always determined by a licensed provider after reviewing your intake.
How to take it
- 1Your provider confirms your starting dose and titration schedule.
- 2Inject once weekly, on the same day each week, exactly as directed.
- 3Doses are usually increased gradually to help limit side effects.
- 4Store as instructed and message your care team for adjustments or questions.
Safety, risks & side effects
GLP-1 medications carry real risks. Review them with a licensed provider and read the full prescribing information before starting.
Boxed warning: In rodent studies, tirzepatide caused thyroid C-cell tumors. It is not known whether it causes these tumors, including medullary thyroid carcinoma (MTC), in humans. Do not use if you or a family member has had MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Common side effects
- Nausea
- Diarrhea or constipation
- Vomiting
- Abdominal pain
- Decreased appetite
Serious risks
- Pancreatitis (inflammation of the pancreas)
- Gallbladder problems
- Low blood sugar, especially with other diabetes medicines
- Kidney problems related to dehydration
- Serious allergic reactions
Do not use if you have
- Personal or family history of medullary thyroid carcinoma
- Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- Known serious allergy to tirzepatide
- Pregnancy or breastfeeding
How it compares
Frequently asked questions
What is compounded tirzepatide?
Compounded tirzepatide is tirzepatide prepared by a licensed compounding pharmacy. It is the same active molecule used in some brand-name medications, taken as a once-weekly injection under provider supervision.
Is tirzepatide well studied?
Tirzepatide is a dual GIP and GLP-1 receptor agonist and the active ingredient in FDA-approved medications such as Mounjaro and Zepbound. You can review the FDA prescribing information for those products for details on approved uses, dosing, and risks. Note that compounded tirzepatide itself is not FDA approved.
How is tirzepatide different from semaglutide?
Semaglutide acts on one gut hormone pathway (GLP-1), while tirzepatide acts on two (GIP and GLP-1). Some women find tirzepatide gives stronger appetite control, but the right option depends on your history and goals. A licensed provider helps you decide.
Can I use compounded tirzepatide during perimenopause or menopause?
Many women come to Josie because weight changes in perimenopause and menopause can be driven by shifting hormones, not only lifestyle. Compounded tirzepatide may be part of a provider-guided plan during this stage. A licensed provider reviews your history, including where you are in the menopause transition, before deciding what is appropriate for you.
How is it taken?
It is a once-weekly injection. Your provider sets your starting dose and a titration schedule, then adjusts it over time based on how you respond.
How soon will I see results?
Responses vary from person to person. GLP-1 care works gradually and alongside nutrition and activity. Your provider will help set realistic expectations based on your health and goals.
How much does it cost, and is there a membership fee?
Josie offers 1, 3, 6, and 12-month plans, with the lowest monthly cost on the longer plans. Your plan price includes the provider review, ongoing messaging, and shipping. There is no separate membership fee, and your price stays the same regardless of your dose. Current pricing is shown in the plan selector above.
Is there a consultation fee?
There is no upfront fee to complete your intake. A $80 consultation fee applies only if a licensed provider approves your care plan and you then choose not to proceed with medication.
Do I need an in-person appointment?
No. Josie is telehealth. You complete an online intake and a licensed provider reviews your health history and goals. If they have questions, your care team follows up by message, so there is no in-person visit required.
Which US states is Josie available in?
Josie is available in all 50 US states.
Which pharmacy fills my prescription?
If a provider prescribes compounded tirzepatide, it is prepared and shipped by a licensed US compounding pharmacy. Month-to-month plans are filled by Strive Pharmacy, only if offered in your state. Reach out to our customer support team at team@joinjosie.com to see if Strive Pharmacy delivers where you live. Multi-month plans may be filled by Casa Pharma or Foothills. Clear instructions are included with your order.
Can I get a refund?
Because compounded medications are made specifically for you, prescription costs generally cannot be refunded once your order is filled. If a provider approves your plan and you choose not to proceed, only the $80 consultation fee applies. Reach out to the care team with any billing questions.
Is compounded tirzepatide FDA approved?
No. Compounded medications are not FDA approved, and the FDA does not review them for safety, effectiveness, or quality before marketing. A licensed provider determines whether compounded tirzepatide is appropriate for you.
How do I start?
Complete the online intake. A licensed Josie provider reviews your history and, if appropriate, prescribes your plan, which is shipped from a licensed pharmacy.
Compounded GLP-1 medications are not FDA approved. The FDA does not review compounded medications for safety, effectiveness, or quality before marketing.
Medications are only issued when clinically appropriate after a provider evaluation. Josie does not manufacture compounded medications, and the actual product appearance may differ from website images.
What to Expect at Josie
- Complete your intake online, from anywhere
- Provider review by Josie's licensed clinicians, supervised by Dr. Ana Lisa Carr, MD
- Transparent program pricing
- Medication shipped from a licensed pharmacy or compounding pharmacy when prescribed