Injectable GLP-1 · Brand name
Zepbound
Brand-name tirzepatide from Eli Lilly, an FDA-approved once-weekly dual GIP and GLP-1 injection for chronic weight management.
- Once-weekly injection
- Brand-name tirzepatide
- FDA-approved for weight management
- Provider-reviewed before prescribed
$1,099/mo
Includes your provider consult and the medication, shipped to you.
Provider-reviewed · Cancel anytime
Every plan includes
- Licensed provider review of your intake
- Brand-name Zepbound shipped to you when prescribed
- Unlimited messaging with your care team and provider
- Free shipping on every order
- Dose adjustments as your provider directs
What it is and how it works
Zepbound is the brand name for tirzepatide, made by Eli Lilly, and it is FDA-approved for chronic weight management. It is a dual GIP and GLP-1 receptor agonist that works on two gut hormone pathways to help regulate appetite and how full you feel.
Zepbound is taken as a once-weekly injection, with the dose increased gradually over time. A Josie provider reviews your health history and intake before any prescription is issued.
Because Zepbound is a brand-name medication, many women compare it to compounded tirzepatide, which uses the same active molecule at a lower price.
Who it’s for
May be a fit if you
- Want the FDA-approved brand-name tirzepatide specifically
- Want a dual-pathway option for appetite control
- Prefer a once-weekly injection pen
- Want licensed provider oversight and ongoing support
Not appropriate if you
- Have a personal or family history of medullary thyroid carcinoma or MEN 2
- Are pregnant, trying to conceive, or breastfeeding
- Have a history of pancreatitis or certain GI conditions (discuss with your provider)
- Are advised against GLP-1 care by your provider
Eligibility is always determined by a licensed provider after reviewing your intake.
How to take it
- 1Your provider confirms your starting dose and titration schedule.
- 2Inject once weekly with the Zepbound pen, on the same day each week.
- 3The dose is increased gradually over several weeks to help limit side effects.
- 4Store as instructed and message your care team for adjustments or questions.
Safety, risks & side effects
GLP-1 medications carry real risks. Review them with a licensed provider and read the full prescribing information before starting.
Boxed warning: In rodent studies, tirzepatide caused thyroid C-cell tumors. It is not known whether Zepbound causes these tumors, including medullary thyroid carcinoma (MTC), in humans. Do not use if you or a family member has had MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Common side effects
- Nausea
- Diarrhea or constipation
- Vomiting
- Abdominal pain
- Decreased appetite
Serious risks
- Pancreatitis (inflammation of the pancreas)
- Gallbladder problems
- Low blood sugar, especially with other diabetes medicines
- Kidney problems related to dehydration
- Serious allergic reactions
Do not use if you have
- Personal or family history of medullary thyroid carcinoma
- Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- Known serious allergy to tirzepatide
- Pregnancy or breastfeeding
Frequently asked questions
What is Zepbound?
Zepbound is the brand name for tirzepatide, made by Eli Lilly. It is a dual GIP and GLP-1 receptor agonist taken as a once-weekly injection and is FDA-approved for chronic weight management.
Is Zepbound FDA approved?
Yes. Unlike compounded tirzepatide, Zepbound is an FDA-approved medication. You can review the FDA prescribing information for details on approved uses, dosing, and risks.
How is Zepbound different from compounded tirzepatide?
Both use tirzepatide as the active molecule. Zepbound is the FDA-approved brand-name product and is typically the highest-cost option. Compounded tirzepatide is prepared by a licensed compounding pharmacy and is usually lower cost, but it is not FDA approved.
How much does it cost, and what is included?
The price shown is per month and includes your provider consult and the medication shipped to you. There is no separate membership fee.
Is there a consultation fee?
There is no upfront fee to complete your intake. A $80 consultation fee applies only if a licensed provider approves your care plan and you then choose not to proceed with medication.
Which US states is Josie available in?
Josie is available in all 50 US states.
How do I start?
Complete the online intake. A licensed Josie provider reviews your history and, if appropriate, prescribes your plan, which is shipped from a licensed pharmacy.
Zepbound is a registered trademark of Eli Lilly and Company. Josie is not affiliated with, endorsed by, or sponsored by Eli Lilly.
Medications are only issued when clinically appropriate after a provider evaluation. Prescription medications carry risks; read the full prescribing information before use.
What to Expect at Josie
- Complete your intake online, from anywhere
- Provider review by Josie's licensed clinicians, supervised by Dr. Ana Lisa Carr, MD
- Transparent program pricing
- Medication shipped from a licensed pharmacy or compounding pharmacy when prescribed