Oral GLP-1 · Compounded
Compounded Oral Tirzepatide ODT
Compounded tirzepatide as an orally dissolving tablet (ODT) that goes under the tongue, no needles, for provider-supervised weight management.
- No needles, dissolves under the tongue
- Tirzepatide, a dual GIP and GLP-1
- Provider-reviewed before prescribed
- Same price at any dose
Every plan includes
- Licensed provider review of your intake
- Compounded oral tirzepatide shipped from a licensed pharmacy when prescribed
- Unlimited messaging with your care team and provider
- Free shipping on every order
- Dose adjustments as your provider directs
What it is and how it works
Tirzepatide is a dual GIP and GLP-1 receptor agonist. It works on two gut hormone pathways that help regulate appetite and how full you feel, which is what sets it apart from single-pathway GLP-1 medications.
This is the oral form: an orally dissolving tablet (ODT) that dissolves under the tongue, so there are no injections. It is often chosen by women who want stronger appetite control without injecting.
Compounded oral tirzepatide is prepared by a licensed compounding pharmacy. A Josie provider reviews your health history and intake before any prescription is issued, and supports you with adjustments over time.
Who it’s for
May be a fit if you
- Would rather avoid needles
- Want a dual-pathway option for appetite control
- Have plateaued on a single-pathway GLP-1
- Want licensed provider oversight and ongoing support
Not appropriate if you
- Have a personal or family history of medullary thyroid carcinoma or MEN 2
- Are pregnant, trying to conceive, or breastfeeding
- Have a history of pancreatitis or certain GI conditions (discuss with your provider)
- Are advised against GLP-1 care by your provider
Eligibility is always determined by a licensed provider after reviewing your intake.
How to take it
- 1Your provider confirms your dose and schedule.
- 2Place the tablet under your tongue and let it dissolve, no water needed.
- 3Follow the schedule your provider sets, and avoid eating or drinking for a short time after, as directed.
- 4Message your care team for adjustments or questions.
Safety, risks & side effects
GLP-1 medications carry real risks. Review them with a licensed provider and read the full prescribing information before starting.
Boxed warning: In rodent studies, tirzepatide caused thyroid C-cell tumors. It is not known whether it causes these tumors, including medullary thyroid carcinoma (MTC), in humans. Do not use if you or a family member has had MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Common side effects
- Nausea
- Diarrhea or constipation
- Vomiting
- Abdominal pain
- Decreased appetite
Serious risks
- Pancreatitis (inflammation of the pancreas)
- Gallbladder problems
- Low blood sugar, especially with other diabetes medicines
- Kidney problems related to dehydration
- Serious allergic reactions
Do not use if you have
- Personal or family history of medullary thyroid carcinoma
- Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- Known serious allergy to tirzepatide
- Pregnancy or breastfeeding
How it compares
Frequently asked questions
What is compounded oral tirzepatide?
It is tirzepatide prepared by a licensed compounding pharmacy as an orally dissolving tablet (ODT). It uses the same active molecule as injectable tirzepatide, taken by mouth instead of by injection, under provider supervision.
What does ODT mean and how do I take it?
ODT stands for orally dissolving tablet. You place it under your tongue and let it dissolve, no needles and no water required. Your provider sets your dose and schedule.
How is tirzepatide different from semaglutide?
Semaglutide acts on one gut hormone pathway (GLP-1), while tirzepatide acts on two (GIP and GLP-1). Some women find tirzepatide gives stronger appetite control. A licensed provider helps you decide which fits your goals.
Is the oral form as effective as the injection?
Both the oral and injectable forms use the same active molecule, but they are absorbed differently and individual responses vary. Injections are the most studied route. A provider helps you choose based on your preferences and goals.
How much does it cost, and is there a membership fee?
Josie offers 1, 3, 6, and 12-month plans, with the lowest monthly cost on the longer plans. Your plan price includes the provider review, ongoing messaging, and shipping. There is no separate membership fee, and your price stays the same regardless of your dose. Current pricing is shown in the plan selector above.
Is there a consultation fee?
There is no upfront fee to complete your intake. A $80 consultation fee applies only if a licensed provider approves your care plan and you then choose not to proceed with medication.
Which US states is Josie available in?
Josie is available in all 50 US states.
Which pharmacy fills my prescription?
If a provider prescribes compounded oral tirzepatide, it is prepared and shipped by a licensed US compounding pharmacy. Month-to-month plans are filled by Strive Pharmacy, only if offered in your state. Reach out to our customer support team at team@joinjosie.com to see if Strive Pharmacy delivers where you live. Multi-month plans may be filled by Casa Pharma or Foothills. Clear instructions are included with your order.
Can I get a refund?
Because compounded medications are made specifically for you, prescription costs generally cannot be refunded once your order is filled. If a provider approves your plan and you choose not to proceed, only the $80 consultation fee applies. Reach out to the care team with any billing questions.
Is compounded oral tirzepatide FDA approved?
No. Compounded medications are not FDA approved, and the FDA does not review them for safety, effectiveness, or quality before marketing. A licensed provider determines whether it is appropriate for you.
How do I start?
Complete the online intake. A licensed Josie provider reviews your history and, if appropriate, prescribes your plan, which is shipped from a licensed pharmacy.
Compounded GLP-1 medications are not FDA approved. The FDA does not review compounded medications for safety, effectiveness, or quality before marketing.
Medications are only issued when clinically appropriate after a provider evaluation. Josie does not manufacture compounded medications, and the actual product appearance may differ from website images.
What to Expect at Josie
- Complete your intake online, from anywhere
- Provider review by Josie's licensed clinicians, supervised by Dr. Ana Lisa Carr, MD
- Transparent program pricing
- Medication shipped from a licensed pharmacy or compounding pharmacy when prescribed