Compounded HRT · Transdermal
Progesterone + Estradiol Body Cream
A compounded transdermal cream combining estradiol and progesterone, used for provider-supervised menopause symptom relief with uterine-lining protection.
- Combines estradiol and progesterone
- Transdermal, applied to the skin
- Progesterone helps protect the uterine lining
- 3-month supply
$299 total
About $100/mo · 3-month supply
Includes your provider consult and medication, shipped to you.
Provider-reviewed · Cancel anytime
Every plan includes
- Licensed provider review of your intake
- Compounded hormone therapy shipped from a licensed pharmacy when prescribed
- Unlimited messaging with your care team and provider
- Free shipping on every order
- Dose adjustments as your provider directs
What it is and how it works
This body cream combines two hormones: estradiol, the main estrogen that declines in menopause, and progesterone. Estradiol addresses symptoms like hot flashes, night sweats, and sleep changes, while progesterone helps protect the lining of the uterus.
Because it is transdermal, the hormones are absorbed through the skin and bypass the first pass through the liver. Research suggests transdermal estrogen may carry a lower risk of blood clots than estrogen taken by mouth.
For women who still have a uterus, estrogen is generally paired with progesterone, since estrogen on its own increases the risk of endometrial cancer. A Josie provider reviews your history and intake before any prescription is issued, and adjusts your plan over time.
Who it’s for
May be a fit if you
- Still have a uterus and want combined estrogen plus progesterone
- Have hot flashes, night sweats, or sleep and mood changes
- Prefer a single transdermal cream over separate products
- Want licensed provider oversight and ongoing support
Not appropriate if you
- Are pregnant, trying to conceive, or breastfeeding
- Have a history of breast cancer or another hormone-dependent cancer
- Have had blood clots, stroke, or a heart attack, or have liver disease
- Have unexplained vaginal bleeding
Eligibility is always determined by a licensed provider after reviewing your intake.
How to use it
- 1Your provider confirms your dose and where to apply the cream.
- 2Apply the measured amount to clean, dry skin as directed.
- 3Rotate application sites and let it absorb before covering with clothing.
- 4Wash your hands after applying, and message your care team with any questions or for adjustments.
Safety, risks & side effects
Combined estrogen plus progestogen therapy carries real risks. Review them with a licensed provider and read the full prescribing information before starting.
Boxed warning: Estrogen plus progestogen therapy should not be used to prevent heart disease or dementia. The Women’s Health Initiative reported increased risks of stroke, blood clots, heart attack, invasive breast cancer, and probable dementia in some women. Progestogen is included to reduce the risk of endometrial cancer from estrogen in women with a uterus. Use the lowest effective dose for the shortest time consistent with your goals, as determined by your provider.
Common side effects
- Breast tenderness
- Headache
- Bloating or mood changes
- Skin irritation at the application site
- Spotting or changes in bleeding
Serious risks
- Blood clots in the legs or lungs
- Stroke
- Heart attack
- Breast cancer
- Gallbladder disease
Do not use if you have
- Known, suspected, or history of breast cancer or hormone-dependent cancer
- History of blood clots, stroke, or heart attack
- Unexplained vaginal bleeding
- Liver disease or pregnancy
How it compares
Frequently asked questions
What is Progesterone + Estradiol Body Cream?
It is a compounded transdermal cream that combines estradiol (estrogen) and progesterone in one product, applied to the skin, used to relieve menopause symptoms while protecting the uterine lining.
Why are estrogen and progesterone combined?
For women who still have a uterus, taking estrogen alone increases the risk of endometrial cancer. Adding progesterone helps protect the uterine lining, which is why the two are usually prescribed together.
Who should choose this over estrogen alone?
Women who still have a uterus generally need both hormones. Women who have had a hysterectomy may only need estrogen. A licensed provider decides based on your history.
How soon will I notice a difference?
Responses vary. Some women notice fewer hot flashes and better sleep within a few weeks, while other benefits build over time. Your provider will set expectations and adjust your dose as needed.
How much does it cost, and is there a membership fee?
Progesterone + Estradiol Body Cream is provided as a 3-month plan. Your plan price includes the provider review, ongoing messaging, and shipping. There is no separate membership fee. Current pricing is shown above.
Is there a consultation fee?
There is no upfront fee to complete your intake. A $80 consultation fee applies only if a licensed provider approves your care plan and you then choose not to proceed with treatment.
Do I need an in-person appointment?
No. Josie is telehealth. You complete an online intake and a licensed provider reviews your health history and goals. If they have questions, your care team follows up by message, so there is no in-person visit required.
Which US states is Josie available in?
Josie is available in all 50 US states.
Is compounded HRT FDA approved?
No. Compounded medications are not FDA approved, and the FDA does not review them for safety, effectiveness, or quality before marketing. FDA-approved hormone therapies also exist. A licensed provider determines whether compounded hormone therapy is appropriate for you.
How do I start?
Complete the online intake. A licensed Josie provider reviews your history and, if appropriate, prescribes your plan, which is shipped from a licensed pharmacy.
Compounded hormone therapy is not FDA approved. The FDA does not review compounded medications for safety, effectiveness, or quality before marketing.
Medications are only issued when clinically appropriate after a provider evaluation. Josie does not manufacture compounded medications, and the actual product appearance may differ from website images.
What to Expect at Josie
- Complete your intake online, from anywhere
- Provider review by Josie's licensed clinicians, supervised by Dr. Ana Lisa Carr, MD
- Transparent program pricing
- Medication shipped from a licensed pharmacy or compounding pharmacy when prescribed