Compounded HRT · Transdermal
Estradiol Cream
Prescription only. Prescribed only if a licensed provider determines it is appropriate for you.
$269 total
About $90/mo · 3-month supply
Includes your provider consult and medication, shipped to you.
Provider-reviewed · Cancel anytime
Safety, risks & side effects
Review these risks with a licensed provider and read the full prescribing information before starting.
Boxed warning: Estrogen-alone therapy increases the risk of endometrial cancer in a woman who still has her uterus, which is why estrogen is usually combined with a progestogen in that case. Estrogens should not be used to prevent heart disease or dementia. Studies have reported increased risks of stroke, blood clots, and, in some women, breast cancer and probable dementia. Use the lowest effective dose for the shortest time consistent with your goals, as determined by your provider.
Common side effects
- Breast tenderness
- Headache
- Nausea
- Skin irritation at the application site
- Spotting or changes in bleeding
Serious risks
- Blood clots in the legs or lungs
- Stroke
- Endometrial cancer if estrogen is used without progesterone in women with a uterus
- Breast cancer
- Gallbladder disease
Do not use if you have
- Known, suspected, or history of breast cancer or estrogen-dependent cancer
- History of blood clots, stroke, or heart attack
- Unexplained vaginal bleeding
- Liver disease or pregnancy
Compounded hormone therapy is not FDA approved. The FDA does not review compounded medications for safety, effectiveness, or quality before marketing.
Medications are only issued when clinically appropriate after a provider evaluation. Josie does not manufacture compounded medications, and the actual product appearance may differ from website images.