Compounded HRT · Vaginal
Progesterone + Estradiol Vaginal Cream
Prescription only. Prescribed only if a licensed provider determines it is appropriate for you.
$299 total
About $100/mo · 3-month supply
Includes your provider consult and medication, shipped to you.
Provider-reviewed · Cancel anytime
Safety, risks & side effects
Review these risks with a licensed provider and read the full prescribing information before starting.
Boxed warning: Estrogen products carry a class warning. Estrogen-alone therapy increases the risk of endometrial cancer in women with a uterus, and studies of systemic estrogen have reported increased risks of stroke, blood clots, and, in some women, breast cancer and probable dementia. Vaginal estrogen is used locally at lower doses; your provider will determine what is appropriate and use the lowest effective dose.
Common side effects
- Vaginal irritation or itching
- Vaginal discharge
- Mild burning at application
- Breast tenderness
- Headache
Serious risks
- Endometrial changes with longer-term use
- Blood clots
- Stroke
- Breast cancer
- Allergic reaction
Do not use if you have
- Known, suspected, or history of breast cancer or hormone-dependent cancer
- Unexplained vaginal bleeding
- History of blood clots or stroke
- Pregnancy
Compounded hormone therapy is not FDA approved. The FDA does not review compounded medications for safety, effectiveness, or quality before marketing.
Medications are only issued when clinically appropriate after a provider evaluation. Josie does not manufacture compounded medications, and the actual product appearance may differ from website images.